R&D

Increased intestinal permeability is now recognized as a key parameter linking diet and the initial symptoms of metabolic dysregulation.

Increased intestinal permeability, commonly referred to as the “leaky gut” is now recognized as a key parameter linking diet and the initial symptoms of metabolic dysregulation including insulin resistance, chronic low-grade inflammation and fatty liver.

The leaky gut is associated with the loss of intestinal wall integrity through the malfunction of tight junctions - the critical structural proteins that maintain the barrier separating pathogenic intestinal contents from the rest of the body.